J.D., American University magna cum laude
Ph.D., Molecular Biology, Princeton University Charlotte Elizabeth Procter Honorific Scholarship
M.D., Albert Szent-Gyorgyi Medical University summa cum laude
United States Patent and Trademark Office
District of Columbia
Dr. Gaszner is a director in the Biotechnology Group where he prosecutes US and international patent applications. He also contributes to the preparation of freedom-to-operate analyses. His technical experience includes molecular biology, genetics, recombinant influenza vaccines and therapeutic antibodies.
Prior to joining the firm, Dr. Gaszner worked as a patent agent at an area biotech company where he prepared and prosecuted US and international patent applications and performed freedom-to-operate analyses on candidate target molecules. Dr. Gaszner's graduate and postdoctoral work primarily focused on the role of chromatin structure in eukaryotic gene regulation.
Dr. Gaszner is fluent in Hungarian.
VEZF1 elements mediate protection from DNA methylation. Dickson J, Gowher H, Strogantsev R, Gaszner M, Hair A, Felsenfeld G, West AG. PLoS Genet. 2010 Jan; 6(1):e1000804.
Insulators: exploiting transcriptional and epigenetic mechanisms. Gaszner M. & Felsenfeld G. Nat Rev Genet 2006 Sep, 7(9):703-13.
Chromatin boundaries and chromatin domains. Felsenfeld G, Burgess-Beusse B, Farrell C, Gaszner M, Ghirlando R, Huang S, Jin C, Litt M, Magdinier F, Mutskov V, Nakatani Y, Tagami H, West A, Yusufzai T. Cold Spring Harb Symp Quant Biol. 2004;69:245-50.
Recruitment of histone modifications by USF proteins at a vertebrate barrier element. West AG*, Huang S*, Gaszner M*, Litt MD and Felsenfeld G. Mol Cell 2004 Nov 5;16(3):453-63 (*These authors contributed equally to this work.)
Protein:protein interactions and the pairing of boundary elements in vivo. Blanton J, Gaszner M, Schedl P. Genes Dev. 2003 Mar 1;17(5):664-75.
The insulation of genes from external enhancers and silencing chromatin. Burgess-Beusse B, Farrell C, Gaszner M, Litt M, Mutskov V, Recillas-Targa F, Simpson M, West A, Felsenfeld G. Proc Natl Acad Sci U S A. 2002 Dec 10;99 Suppl 4:16433-7.
Position-effect protection and enhancer blocking by the chicken beta-globin insulator are separable activities. Recillas-Targa F, Pikaart MJ, Burgess-Beusse B, Bell AC, Litt MD, West AG, Gaszner M, Felsenfeld G. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6883-8.
Insulators: many functions, many mechanisms. West AG*, Gaszner M*, Felsenfeld G. Genes Dev. 2002 Feb 1;16(3):271-88. (*These authors contributed equally to this work.)
Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus. Litt MD, Simpson M, Gaszner M, Allis CD, Felsenfeld G. Science. 2001 Sep 28;293(5539):2453-5.
The zw5 protein, a component of the scs chromatin domain boundary, is able to block enhancer-promoter interaction. Gaszner M, Vazquez J and Schedl P. Genes Dev. 1999 Aug 15;13(16):2098-107
Spermidine-induced alteration in the gene-spacer discrimination of nucleases in protonated DNA. Gaszner M, Haracska L and Udvardy A. Arch. Biochem. Biophys. 1993. 303(1):1-9
Genetic and molecular analysis of chromatin domains. Vazquez J, Farkas G, Gaszner M, Udvardy A, Muller M, Hagstrom K, Gyurkovics H, Sipos L, Gausz J, Galloni M, Hogga I, Karch F and Schedl P. Cold Spring Harb. Symp. Quant. Biol. 1993. 58:45-54
Purification of a lysosomal DNase from Drosophila melanogaster. Gaszner M and Udvardy A. Biochem. Biophys. Res. Commun. 1991. 181(1)44-50
The isolated N-terminal DNA binding domain of the c repressor of bacteriophage 16-3 is functional in DNA binding in vivo and in vitro. Dallmann G, Marincs F, Papp P, Gaszner M and Orosz L. Mol. Gen. Genet. 1991. 227(1):106-12
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